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Updated: May 9, 2026
10:59
Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
Published on: November 19, 2012
[The child's brain: normal (unaltered) development and development altered by perinatal injury].
1Dartmouth Medical School, NH 03755 Hanover, EE.UU.
Revista De Neurologia
|July 31, 2013
Summary
Perinatal brain injuries cause local damage that alters brain development. These changes can spread to connected regions, impacting a child's neurological and psychological growth.
Area of Science:
- Neuroscience
- Developmental Biology
- Neuropathology
Context:
- Child brain development involves progressive interconnection of regions.
- Perinatal injuries, such as hemorrhages and white matter infarcts, disrupt normal development.
- Brain lesions cause local alterations with potential remote effects.
Purpose:
- To analyze morphological and functional changes in normal and altered child brain development.
- To detail neuropathological development of specific perinatal injuries.
- To investigate how local brain lesions affect interconnected regions.
Summary:
- Brain damage alters local components like neurons and glial cells, leading to transformed cell structures and altered reinnervation/revascularization.
- Grey matter's microvasculature protects neurons from white matter infarcts, but disconnection from fibers impairs function.
- Local lesions can modify morphology and function in interconnected remote regions, impacting neurological and psychological development.
Impact:
- Understanding how perinatal injuries affect brain development is crucial for predicting and managing long-term neurological and psychological outcomes.
- Identifying the spread of injury effects across interconnected brain regions can inform targeted interventions.
- This research highlights the potential for local brain damage to trigger widespread functional and morphological alterations, including conditions like epilepsy.
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