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Published on: January 19, 2019
HepPar-1 expression in primary lung adenocarcinoma
Samuel A Yousem1, Seema Lale, Sanja Dacic
1Department of Pathology, UPMC Presbyterian Shadyside, Presbyterian Campus-A610, 200 Lothrop St, Pittsburgh, PA 15213-2582, USA. yousemsa@upmc.edu
Objectives:
To study a subset of lung adenocarcinomas with aberrant HepPar-1 antigen expression.
Methods:
We performed a clinicopathologic review of 16 cases.
Results:
Of 241 primary lung adenocarcinomas tested for expression of the HepPar-1 antigen, 16 (6.6%) were positive. The cases occurred in older smokers with an equal sex distribution. Morphologically, these pulmonary adenocarcinomas had an acinar-predominant architecture, and prominent cribriform growth, with HepPar-1-expressing tumor cells being uniformly columnar with abundant bipolar lightly eosinophilic cytoplasm. HepPar-1 was coexpressed with thyroid transcription factor 1 in 94% of cases. No EGFR mutations were identified, while 31% of cases were positive for KRAS codon 12 mutations.
Conclusions:
Although aberrant HepPar-1 expression was frequently seen in tumors with visceral pleural and angiolymphatic invasion, its prognostic significance is uncertain.
