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HepPar-1 expression in primary lung adenocarcinoma
Samuel A Yousem1, Seema Lale, Sanja Dacic
1Department of Pathology, UPMC Presbyterian Shadyside, Presbyterian Campus-A610, 200 Lothrop St, Pittsburgh, PA 15213-2582, USA. yousemsa@upmc.edu
American Journal of Clinical Pathology
|July 31, 2013
Summary
A subset of lung adenocarcinomas (6.6%) showed aberrant HepPar-1 antigen expression, often coexpressed with thyroid transcription factor 1. The prognostic significance of HepPar-1 in lung cancer remains uncertain.
Area of Science:
- Oncology
- Pathology
- Molecular Biology
Background:
- Aberrant HepPar-1 antigen expression is observed in a subset of primary lung adenocarcinomas.
- This finding is particularly relevant in the context of differential diagnosis and molecular profiling of lung neoplasms.
Purpose of the Study:
- To investigate the clinicopathologic features of lung adenocarcinomas exhibiting aberrant HepPar-1 expression.
- To determine the coexpression patterns with other markers and identify associated genetic mutations.
Main Methods:
- Clinicopathologic review of 16 lung adenocarcinoma cases with HepPar-1 expression.
- Immunohistochemical analysis for HepPar-1 and thyroid transcription factor 1 (TTF-1).
- Mutation analysis for EGFR and KRAS (codon 12).
Main Results:
- HepPar-1 expression was identified in 6.6% (16/241) of primary lung adenocarcinomas.
- Cases typically presented in older smokers, with acinar-predominant and cribriform morphology.
- HepPar-1 coexpressed with TTF-1 in 94% of cases; 31% harbored KRAS codon 12 mutations, and no EGFR mutations were found.
Conclusions:
- Aberrant HepPar-1 expression in lung adenocarcinoma is associated with specific morphological features and KRAS mutations.
- Frequent coexpression with TTF-1 suggests a potential role in lineage determination.
- The prognostic significance of HepPar-1 in lung adenocarcinoma, despite association with invasion, requires further investigation.
