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A material-sparing method for assessment of powder deformation characteristics using data collected during a single
Jeffrey M Katz1, Rahul Roopwani, Ira S Buckner
1Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania, 15282.
Journal of Pharmaceutical Sciences
|July 31, 2013
Summary
This study introduces a novel method to accurately measure powder compressibility using in-die data, correcting for elastic and viscoelastic recovery. This approach streamlines tablet development and improves productivity by providing comprehensive powder characterization.
Area of Science:
- Materials Science
- Pharmaceutical Engineering
- Powder Technology
Background:
- Compressibility profiles are crucial for understanding powder mechanical behavior during compaction.
- In-die and out-of-die measurements offer distinct advantages but are typically performed separately.
- Accurate compressibility data is vital for tablet formulation and development.
Purpose of the Study:
- To develop a method for generating complete out-of-die compressibility profiles from in-die data.
- To correct for elastic and viscoelastic recovery during powder compaction.
- To provide a precise and accurate evaluation of powder compressibility.
Main Methods:
- Utilizing data from a single compression-decompression cycle performed in-die.
- Applying corrections for elastic and viscoelastic recovery.
- Evaluating the method's precision and accuracy with four common tableting excipients.
Main Results:
- The in-die method accurately generates complete out-of-die compressibility profiles.
- The method effectively corrects for elastic and viscoelastic recovery.
- Demonstrated precision and accuracy for common tableting excipients.
Conclusions:
- This computationally simple and material-sparing method enables comprehensive characterization of powder compaction behavior.
- It improves understanding of plastic/brittle, elastic, and viscoelastic deformation.
- The approach can enhance productivity and streamline tablet development studies.
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