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Cigarette smoking and acute nonlymphocytic leukemia
R K Severson1, S Davis, L Heuser
1Div. of Epidemiology, U. of Minnesota, Minneapolis, MN 55455.
American Journal of Epidemiology
|September 1, 1990
Summary
Cigarette smoking is linked to a doubled risk of acute nonlymphocytic leukemia (ANLL). The risk escalates with smoking intensity and duration, but diminishes after quitting.
Area of Science:
- Epidemiology
- Oncology
- Public Health
Background:
- Acute nonlymphocytic leukemia (ANLL) is a significant health concern.
- Cigarette smoking is a widespread behavior with known health risks.
Purpose of the Study:
- To investigate the association between cigarette smoking and the risk of acute nonlymphocytic leukemia (ANLL).
Main Methods:
- A case-control study was conducted in western Washington state.
- The study compared smoking habits of ANLL patients with a control group.
Main Results:
- Smokers had a twofold increased risk of ANLL compared to nonsmokers.
- Risk significantly increased with pack-years smoked (p=0.0008).
- Risk decreased with years since quitting smoking (p=0.15), and was more pronounced in those inhaling smoke into the chest.
Conclusions:
- Cigarette smoking is a potential risk factor for acute nonlymphocytic leukemia.
- Further research is warranted given the high prevalence of smoking.