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Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
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Cerebral glucose metabolism on positron emission tomography of children

Zuyao Y Shan1, Andrew J Leiker, Arzu Onar-Thomas

  • 1Centre for Advanced Imaging, University of Queensland, Brisbane St Lucia, Queensland, Australia.

Human Brain Mapping
|July 31, 2013
PubMed

Insights

This study establishes normative ranges for fluorodeoxyglucose (FDG) uptake in the developing brain using PET/CT scans. These findings provide essential age-associated data for quantitative analysis of pediatric brain imaging and development.

Area of Science:

  • Neuroimaging
  • Developmental Neuroscience
  • Radiochemistry

Background:

  • Establishing normative ranges for fluorodeoxyglucose (FDG) uptake in the developing brain is crucial for accurate quantitative analysis of pediatric positron emission tomography (PET) brain images.
  • Understanding age-dependent cerebral FDG uptake provides functional insights into brain development.

Purpose of the Study:

  • To investigate age-related changes in FDG uptake in the developing brain.
  • To establish age-associated normative ranges for cerebral FDG uptake in pediatric patients.

Main Methods:

  • Analysis of FDG PET/CT head sections from 115 patients (5 months to 23 years) without central nervous system disease.
  • Registration of PET/CT images to a probabilistic atlas, defining 56 gray matter brain structures.
  • Calculation and statistical modeling of relative standardized uptake values (SUVs) over the cerebellum, accounting for age and structure as significant factors.

Main Results:

  • Significant age and brain structure effects on FDG uptake (SUVs) were identified.
  • Both linear and quadratic developmental trajectories were observed for absolute and relative SUVs.
  • A posterior-to-anterior and superior-to-inferior pattern of SUV increase rate and peak age was noted.

Conclusions:

  • Modeled age-dependent SUV data for brain structures serve as baselines for quantitative analysis of pediatric cerebral FDG-PET images.
  • This research provides critical normative data for interpreting brain development in children using PET imaging.

Keywords:
FDG-PETSUVsbrain imagingchild developmentglucose metabolism

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