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Updated: May 9, 2026

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Total syntheses of amphidinolides T1, T3, and T4
J Stephen Clark1, Filippo Romiti
1WestCHEM, School of Chemistry, University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ (UK) http://www.chem.gla.ac.uk/staff/stephenc/. stephen.clark@glasgow.ac.uk.
Abstract:
Concise and high-yielding total syntheses of amphidinolides T1, T3, and T4 have been completed using an alkynyl macrolactone as a common late-stage intermediate. The required α-hydroxy ketone motif was installed by sequential alkyne hydrosilylation, epoxidation, and Fleming-Tamao oxidation. An oxonium ylide rearrangement formed the trisubstituted tetrahydrofuran core found in the natural products.
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