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Psychotropic drugs as potential antitumor agents: a selective screening study.
Cancer Treatment Reports
|January 1, 1978
Summary
Psychotropic drugs were screened for anticancer activity, revealing significant efficacy against murine L1210 leukemia. This research identified novel antitumor agents with potential central nervous system applications.
Area of Science:
- Pharmacology
- Oncology
- Neuroscience
Background:
- Psychotropic drugs, excluding barbiturates and hallucinogens, were evaluated for antitumor properties.
- The study aimed to discover novel anticancer agents with potential central nervous system (CNS) activity.
Purpose of the Study:
- To identify psychotropic compounds with reproducible antitumor activity.
- To explore the potential of CNS-active agents in cancer treatment.
Main Methods:
- 297 psychotropic drugs were screened against murine L1210 leukemia and B16 melanoma.
- Activity was assessed using T/C values, with a threshold of 125% for confirmed activity.
Main Results:
- Sixteen agents showed reproducible activity against L1210 leukemia.
- Phenothiazines and butyrophenones were prominent active structural types; dopamine was also active.
- Most L1210-active agents were effective against P388 tumors and KB cells in vitro.
Conclusions:
- Psychotropic drug screening yielded a high rate of active antitumor compounds against L1210 leukemia.
- This approach identified promising leads for novel anticancer therapies, particularly those targeting CNS-related tumors.