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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

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Related Experiment Video

Updated: May 9, 2026

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)

Published on: August 21, 2016

A functional genomic perspective on human well-being.

Barbara L Fredrickson1, Karen M Grewen, Kimberly A Coffey

  • 1Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Proceedings of the National Academy of Sciences of the United States of America
|July 31, 2013
PubMed
Summary
This summary is machine-generated.

Psychological well-being impacts gene expression differently. Eudaimonic well-being down-regulates stress responses, while hedonic well-being up-regulates them, revealing distinct molecular pathways.

Keywords:
gene regulationsocial genomics

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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Related Experiment Videos

Last Updated: May 9, 2026

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)

Published on: August 21, 2016

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Area of Science:

  • Molecular biology
  • Psychoneuroimmunology
  • Genomics

Background:

  • Psychological well-being is linked to health benefits.
  • Distinct types of well-being, hedonic and eudaimonic, may have different biological underpinnings.
  • Understanding these mechanisms can inform health interventions.

Purpose of the Study:

  • To investigate the molecular mechanisms connecting psychological well-being and health.
  • To compare the gene expression profiles associated with hedonic and eudaimonic well-being.
  • To identify the cellular and transcriptional factors involved.

Main Methods:

  • Analysis of leukocyte basal gene expression in 80 healthy adults.
  • Assessment of hedonic and eudaimonic well-being, controlling for confounding factors.
  • Bioinformatic analysis of transcription factor activity and transcript origin.

Main Results:

  • Hedonic and eudaimonic well-being exhibited divergent transcriptome profiles despite similar affective correlates.
  • High hedonic well-being correlated with up-regulated conserved transcriptional response to adversity (CTRA), including proinflammatory genes.
  • High eudaimonic well-being correlated with CTRA down-regulation, involving distinct transcription factor signaling pathways (NF-κB, AP-1, IRF, STAT).

Conclusions:

  • Hedonic and eudaimonic well-being activate distinct gene regulatory programs.
  • Monocytes, plasmacytoid dendritic cells, and B lymphocytes are key cellular mediators.
  • The human genome may be more sensitive to qualitative variations in well-being than conscious experience.