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09:10
Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
Published on: July 27, 2022
Radiation-induced esophagitis exacerbated by everolimus
Yuji Miura1, Koichi Suyama, Akihiko Shimomura
1Departments of Medical Oncology, Toranomon Hospital, Tokyo, Japan.
Case Reports in Oncology
|July 31, 2013
Summary
Everolimus, an mTOR inhibitor, may worsen radiation-induced esophagitis in renal cell carcinoma patients. This case highlights potential toxicity when combining everolimus with radiotherapy.
Area of Science:
- Oncology
- Pharmacology
Background:
- Everolimus (mTOR inhibitor) shows anticancer effects, including in renal cell carcinoma (RCC).
- Limited data exists on combining everolimus with radiotherapy.
Observation:
- A 63-year-old man with RCC received radiotherapy for vertebral metastases.
- Everolimus was administered sequentially after radiotherapy.
- The patient developed dysphagia, nausea, and vomiting.
Findings:
- Endoscopic examination revealed erosive esophagitis within the radiation field.
- The esophagitis correlated with the thoracic esophagus irradiation area.
Implications:
- Everolimus may exacerbate radiation-induced esophagitis.
- Clinicians should consider this potential toxicity when using sequential everolimus and radiotherapy.
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