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[Necrotising soft-tissue infections: diagnostics and treatment]
Frank P Garssen1, J Carel Goslings, Catherine S C Bouman
1Academisch Medisch Centrum, Afd. Chirurgie, Trauma Unit, Amsterdam, the Netherlands.
Nederlands Tijdschrift Voor Geneeskunde
|August 1, 2013
Summary
Necrotising soft-tissue infections are severe infections requiring prompt medical attention. Early diagnosis via biopsy and Gram staining, combined with antibiotics and surgical debridement, has significantly reduced mortality rates.
Area of Science:
- Infectious Diseases
- Surgical Pathology
Background:
- Necrotising soft-tissue infections (NSTIs) are severe, life-threatening infections affecting multiple tissue layers.
- Despite low incidence, healthcare professionals will encounter NSTIs during their careers.
Purpose of the Study:
- To review the diagnosis and management of necrotising soft-tissue infections.
- To highlight advancements in treatment leading to reduced mortality.
Main Methods:
- Review of current diagnostic standards, including biopsy and Gram staining.
- Discussion of established and controversial treatment modalities.
Main Results:
- Mortality for NSTIs has decreased from nearly 40% to 20% in the last 15 years.
- Prompt resuscitation, broad-spectrum antibiotics, and surgical debridement are key treatment components.
Conclusions:
- Adequate treatment has halved NSTI mortality.
- Multidisciplinary care and intensive care unit admission are crucial for septic patients.
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