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Updated: May 9, 2026

Modeling the Functional Network for Spatial Navigation in the Human Brain
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Functional brain hubs and their test-retest reliability: a multiband resting-state functional MRI study.

Xu-Hong Liao1, Ming-Rui Xia, Ting Xu

  • 1Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China.

Neuroimage
|August 1, 2013
PubMed
Summary

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High temporal resolution resting-state fMRI reliably detects human brain functional hubs, particularly in default-mode and sensorimotor regions. A 6-minute scan is sufficient, offering insights beyond traditional methods.

Area of Science:

  • Neuroimaging
  • Human Brain Connectomics
  • Functional MRI

Background:

  • Resting-state fMRI (R-fMRI) identifies brain functional hubs, but traditional low sampling rates limit temporal information.
  • High sampling rates in R-fMRI are crucial for reliable connectome characterization and reducing physiological noise.

Purpose of the Study:

  • To identify global functional hubs in human brain networks using high temporal resolution R-fMRI data.
  • To assess the test-retest reliability of these functional hubs.
  • To compare findings with traditional R-fMRI data and explore high-frequency bands.

Main Methods:

  • Utilized a multiband R-fMRI dataset with a sub-second sampling rate (TR=645 ms).
  • Identified voxel-wise functional networks and global hubs.
Keywords:
ConnectomeDefault-modeFunctional connectivityGlobal signalsGraph theoryfMRI

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  • Examined test-retest reliability using intraclass correlation coefficients.
  • Compared results with traditional R-fMRI (TR=2500 ms) and analyzed high-frequency bands (0.2-0.3 Hz).

    • Main Results:

    • Functional hubs were primarily located in default-mode, sensorimotor, and visual cortices.
    • Hubs showed distance-dependent organization (short-range in primary cortex, long-range in association cortex).
    • Most hubs exhibited fair to good test-retest reliability, detectable within a 6-minute scan.
    • High-frequency bands revealed hubs not detected by traditional R-fMRI.

    Conclusions:

    • Multiband R-fMRI with high temporal resolution reliably detects functional brain hubs.
    • High temporal resolution R-fMRI is valuable for studying brain connectomes in health and disease.
    • Findings support the acquisition of high temporal resolution R-fMRI data for advanced neuroimaging research.