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Related Experiment Videos

Primary hypothyroidism and human spermatogenesis.

J J Corrales Hernández1, J M Miralles García, L C García Diez

  • 1Departamento de Medicina, Hospital Clínico Universitario, Salamanca, Spain.

Archives of Andrology
|January 1, 1990
PubMed
Summary
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Hypothyroidism in men can cause slight decreases in seminal volume and sperm motility. However, it does not significantly impact sperm count or morphology, and does not typically cause infertility.

Area of Science:

  • Endocrinology
  • Reproductive Medicine
  • Andrology

Background:

  • Primary hypothyroidism can affect various bodily functions.
  • Spermatogenesis, the process of sperm production, is sensitive to hormonal changes.
  • The impact of induced hypothyroidism on male fertility parameters requires further investigation.

Purpose of the Study:

  • To investigate the effects of induced hypothyroidism on spermatogenic function in men.
  • To compare seminal parameters and hormonal levels in hypothyroid men with fertile controls.
  • To determine if short-term postpuberal hypothyroidism leads to male infertility.

Main Methods:

  • Ten patients with primary hypothyroidism underwent induced hypothyroid states by adjusting levothyroxine treatment.
  • Seminal analysis (volume, density, motility, morphology) was performed.

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  • Circulating levels of testosterone and gonadotropins were measured.
  • Results were compared to 16 proven fertile controls and to the same patients in a euthyroid state.

    • Main Results:

    • Hypothyroid men showed statistically significant decreases in seminal volume (p<0.05), progressive forward motility (p<0.01), and cumulative mobile forms (p<0.01) compared to controls.
    • No significant anomalies were observed in sperm density or normal morphology.
    • No alterations in circulating testosterone or gonadotropin levels were found.
    • No significant seminal or hormonal modifications were noted when comparing hypothyroid state to euthyroid state in the same patients.

    Conclusions:

    • Short-term induced hypothyroidism in men leads to mild seminal alterations, primarily affecting motility and volume.
    • These alterations are not severe enough to cause male infertility.
    • Hormonal profiles (testosterone, gonadotropins) remain unaffected by short-term hypothyroidism.