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Published on: November 29, 2018
Improved motility of retrograde ejaculates by adding donor seminal plasma
1UMDNJ, Robert Wood Johnson Medical School, Cooper Hospital/University Medical Center, Department of Obstetrics/Gynecology, Camden.
Archives of Andrology
|January 1, 1990
Summary
Donor seminal plasma improved sperm motility in infertile men with retrograde ejaculation, leading to successful pregnancies. This suggests seminal fluid quality impacts sperm function and fertility outcomes.
Area of Science:
- Reproductive Medicine
- Andrology
- Infertility Research
Background:
- Sperm motility issues (asthenozoospermia) can stem from seminal fluid defects, not just intrinsic sperm problems.
- Retrograde ejaculation can complicate fertility assessments and treatments.
- Donor seminal plasma (DSP) is a potential medium for sperm manipulation.
Purpose of the Study:
- To investigate the efficacy of donor seminal plasma (DSP) in enhancing sperm progressive forward motion (PFM) in men with asthenozoospermia due to retrograde ejaculation.
- To assess the potential of DSP-treated sperm for achieving pregnancy.
Main Methods:
- Sperm samples from three men with asthenozoospermia and retrograde ejaculation were analyzed.
- Sperm motility was assessed after suspension in Ham's F-10 medium and subsequently in donor seminal plasma (DSP).
- Intracervical insemination with DSP-treated sperm was performed for eligible couples.
Main Results:
- Sperm demonstrated improved progressive forward motion (PFM) when suspended in donor seminal plasma (DSP) compared to Ham's F-10 medium.
- All three participating men achieved pregnancies in their partners within nine ovulatory cycles.
- DSP suspension significantly enhanced sperm motility in the study cohort.
Conclusions:
- Donor seminal plasma (DSP) can effectively improve sperm motility in infertile males with asthenozoospermia associated with retrograde ejaculation.
- DSP treatment facilitated successful pregnancies, highlighting its therapeutic potential.
- Further research is warranted to explore DSP's application in asthenozoospermia cases without retrograde ejaculation.
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