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Related Concept Videos

Structure of Lipids03:38

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...
Structure of Lipids03:38

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...
Structure of Lipids03:38

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
Lipids as Anchors01:32

Lipids as Anchors

In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains the...
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...

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Related Experiment Video

Updated: May 9, 2026

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
09:39

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages

Published on: May 30, 2013

Linoleic acid: between doubts and certainties.

Benjamin Choque1, Daniel Catheline, Vincent Rioux

  • 1Laboratoire de Biochimie et Nutrition Humaine, INRA USC 2012, Agrocampus Ouest, 65 rue de Saint Brieuc, 35042 Rennes cedex, France.

Biochimie
|August 1, 2013
PubMed
Summary
This summary is machine-generated.

Current linoleic acid (LA) recommendations may be overestimated. This review questions excessive LA intake, exploring its link to inflammation and metabolic diseases, and calls for further human studies.

Keywords:
ExcessInflammationLinoleic acidMetabolic diseasesRequirement

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Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
09:26

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis

Published on: November 17, 2011

Related Experiment Videos

Last Updated: May 9, 2026

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
09:39

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages

Published on: May 30, 2013

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
09:26

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis

Published on: November 17, 2011

Area of Science:

  • Nutrition Science
  • Biochemistry
  • Human Physiology

Background:

  • Linoleic acid (LA) is a primary polyunsaturated fatty acid in human diets, with current US intake around 14g/day.
  • Historically considered essential, recent research questions the established dietary requirements for LA.
  • Concerns exist regarding the health implications of excessive LA consumption.

Purpose of the Study:

  • To re-evaluate the recommended dietary intake of linoleic acid.
  • To investigate the molecular mechanisms linking dietary LA levels to physiological roles.
  • To highlight the need for human studies isolating linoleic acid as a variable.

Main Methods:

  • Literature review of existing studies on linoleic acid metabolism and health effects.
  • Analysis of the relationship between linoleic acid, its metabolites, and inflammatory pathways.
  • Identification of knowledge gaps in human physiological responses to varying linoleic acid intake.

Main Results:

  • Evidence suggests linoleic acid intake may be overestimated and linked to inflammation and metabolic diseases.
  • LA is a precursor to arachidonic acid, which generates pro-inflammatory eicosanoids and endocannabinoids.
  • A majority of studies indicate a connection between LA and inflammatory processes.

Conclusions:

  • The established dietary requirement for linoleic acid warrants reconsideration.
  • Further research is crucial to understand the molecular basis of LA's physiological functions.
  • Human studies focusing solely on linoleic acid are necessary to clarify its health impacts.