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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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Related Experiment Video

Updated: May 9, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

The evolving epigenome.

Dieter Weichenhan, Christoph Plass

    Human Molecular Genetics
    |August 1, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Epigenetic alterations, including DNA methylation and noncoding RNAs, are crucial for development and disrupted in diseases like cancer. Recent advances reveal novel DNA modifications, gene mutations, and new technologies for epigenetic profiling.

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    Methylated DNA Immunoprecipitation

    Published on: January 2, 2009

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    Last Updated: May 9, 2026

    An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
    10:41

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    Published on: April 5, 2018

    Pattern-based Search of Epigenomic Data Using GeNemo
    06:38

    Pattern-based Search of Epigenomic Data Using GeNemo

    Published on: October 8, 2017

    Methylated DNA Immunoprecipitation
    21:24

    Methylated DNA Immunoprecipitation

    Published on: January 2, 2009

    Area of Science:

    • Epigenetics and molecular biology
    • Genomics and disease mechanisms
    • Biotechnology and diagnostics

    Background:

    • Epigenetic mechanisms (DNA methylation, histone modifications, chromatin remodeling, noncoding RNAs) regulate crucial cellular processes.
    • Aberrant epigenetic patterns are implicated in various human diseases, particularly cancer.
    • Understanding normal epigenetic landscapes is key to deciphering disease-associated alterations.

    Purpose of the Study:

    • To review recent advances in the field of epigenetics.
    • To highlight novel DNA modifications, ncRNAs, and their roles in disease.
    • To discuss emerging technologies for epigenetic profiling.

    Main Methods:

    • Review of current literature on DNA methylation, histone modifications, chromatin remodeling, and noncoding RNAs.
    • Analysis of recent discoveries in epigenetic alterations in human diseases, focusing on cancer.
    • Examination of novel technologies for high-resolution epigenetic profiling.

    Main Results:

    • Emerging understanding of novel DNA modifications like 5-hydroxymethylation and associated enzymes (TET1-3).
    • Identification of recurrent mutations in epigenetic regulators (e.g., SMARCB1, H3F3A) linked to specific cancers.
    • Characterization of noncoding RNAs (e.g., CTBP1-AS, CDR1as) involved in cancer pathogenesis.
    • Development of new technologies enabling high-resolution epigenetic profiling with small cell numbers.

    Conclusions:

    • Epigenetic research is rapidly advancing, revealing new layers of gene regulation and disease mechanisms.
    • Novel epigenetic marks and mutations represent potential therapeutic targets and biomarkers for cancer.
    • Emerging technologies promise to revolutionize the study of epigenetics in health and disease.