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Related Experiment Video

Updated: May 9, 2026

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

Pathophysiology of subcutaneous fat.

A Cassisa¹

¹Servizio di Anatomia Patologica, Ospedale C. Poma, Mantova - angelo.cassisa@aopoma.it.

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia

|August 1, 2013

Summary

Adipose tissue, composed of adipocytes, is a complex organ regulating metabolism and immunity, not just fat storage. Understanding its role is key to developing new treatments for systemic and skin diseases.

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Last Updated: May 9, 2026

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

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Published on: August 16, 2020

Human Subcutaneous Adipose Tissue Sampling Using a Mini-Liposuction Technique

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Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping

Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping

Published on: October 27, 2020

Area of Science:

Endocrinology
Immunology
Dermatology

Background:

Adipocytes, traditionally viewed as passive fat storage cells, are now recognized as key components of a complex endocrine and immune organ.
Adipose tissue's functional complexity varies by anatomical site, challenging earlier notions of structural uniformity.

Purpose of the Study:

To review the pathophysiology of adipose tissue, highlighting recent scientific advancements.
To emphasize the role of adipokines in both systemic and cutaneous diseases.
To explore new therapeutic strategies for diseases linked to adipose tissue dysfunction.

Main Methods:

Literature review focusing on recent scientific acquisitions regarding adipose tissue.
Analysis of the role of adipocytes and adipokines in metabolic and immune functions.
Examination of the paracrine activity of adipose tissue on skin homeostasis.

Main Results:

Adipose tissue is a sophisticated organ involved in energy storage, metabolic management, and immune system regulation.
Adipose tissue communicates with the brain and influences other organ systems.
Adipokines produced by adipocytes significantly impact various systemic and skin diseases.

Conclusions:

A deeper understanding of adipose tissue pathophysiology is crucial for advancing therapeutic strategies.
Targeting adipose tissue and its signaling molecules offers promising avenues for treating metabolic, immune, and dermatological conditions.
Recognizing adipose tissue as a dynamic endocrine organ opens new perspectives in disease management.