Related Experiment Video
Updated: May 9, 2026
03:42
Retroperitoneal Laparoscopic Debridement and Drainage for Pancreatic Abscess
Published on: March 15, 2024
Infectious panniculitides: an update.
1Operative Unit of Anatomy and Citohistopathology San Bortolo Hospital, Vicenza, Italy - antonio.perasole@ulssvicenza.it.
Summary
Diagnosing infectious panniculitis is challenging due to overlapping microscopic patterns and uncertain causes. This review details the pathophysiology and diagnostic clues for frequent infectious panniculitides, aiding accurate histopathological identification.
Area of Science:
- Dermatopathology
- Histopathology
- Immunology
Background:
- Panniculitis diagnosis is complex, often showing overlapping microscopic features and unclear etiology.
- Traditional classification based on inflammation location and vasculitis has limitations.
- Infectious panniculitides present diagnostic challenges, especially when causative agents are not readily identified.
Purpose of the Study:
- To review the pathophysiology of adipose tissue in panniculitis concerning immunity and host reactions.
- To discuss the microscopic features of common infectious panniculitides.
- To highlight diagnostic clues and ancillary techniques for identifying infectious panniculitides.
Main Methods:
- Literature review focusing on pathophysiology, clinical manifestations, and histopathology of infectious panniculitides.
- Discussion of diagnostic challenges and differential diagnoses.
- Emphasis on the role of clinical history, physical examination, and laboratory studies.
- Integration of immunohistochemistry and molecular biology techniques in diagnosis.
Main Results:
- Panniculitis diagnosis requires differentiating infectious causes from reactive mimics through tissue biopsy.
- Microscopic recognition of specific infections in subcutaneous tissue often necessitates comprehensive clinical information.
- Diverse pathogens can cause varied clinical and histopathological presentations.
Conclusions:
- Accurate diagnosis of infectious panniculitides relies on integrating clinical, histopathological, and microbiological data.
- Ancillary techniques like immunohistochemistry and molecular biology are crucial for identifying elusive causative agents.
- Understanding adipose tissue's immune response is key to unraveling panniculitis pathophysiology.
Related Concept Videos
01:25Acute Pancreatitis I: Introduction
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
01:27Acute Pancreatitis I: Introduction
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:30Acute Pancreatitis II: Clinical Manifestations and Management
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
01:21Acute Pancreatitis II: Pathophysiology
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
01:22Pericarditis I: Introduction
Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
01:25Chronic Pancreatitis I: Introduction
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...