Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Microbial Phylogeny01:28

Microbial Phylogeny

Understanding the evolutionary relationships among microorganisms is fundamental to microbial ecology and taxonomy. Phylogenetic trees are essential tools for inferring these relationships, relying primarily on comparative analyses of molecular sequences such as DNA, RNA, or proteins. In microbial studies, these trees typically depict the evolutionary paths of diverse bacterial and archaeal species by mapping genetic differences accumulated over time.Phylogenetic trees are composed of tips,...
Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Biofuels01:25

Biofuels

The microbial conversion of organic matter into biofuels holds potential as a renewable energy source. Among biofuel sources, microalgae are recognized as a highly efficient and adaptable feedstock for biodiesel production, owing to their rapid biomass accumulation, elevated lipid productivity, and capacity to proliferate in diverse aquatic systems, including freshwater, marine, and wastewater habitats. Unlike terrestrial crops, microalgae do not compete for land and can achieve significantly...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LAMP2A-dependent chaperone mediated autophagy regulates Notch signaling and controls neural stem cell differentiation.

Cellular and molecular life sciences : CMLS·2026
Same author

Breast milk exosomes: Implications for Brain function and Oncogenesis.

Neuroscience and biobehavioral reviews·2026
Same author

Novel Disease-Specific Panel of Salivary microRNAs for the Detection of Oral Squamous Cell Carcinoma from Early Invasion to Stage IV Disease.

International journal of molecular sciences·2026
Same author

DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses.

The Journal of experimental medicine·2026
Same author

Stress-related disorders and nonpeptidic CRH antagonists.

Hormones (Athens, Greece)·2026
Same author

Uncovering EMT-Associated Molecular Mechanisms Through Integrative Transcriptomic and Machine Learning Analyses.

Frontiers in bioscience (Landmark edition)·2026

Related Experiment Video

Updated: May 9, 2026

High-Throughput Metabolic Profiling for Model Refinements of Microalgae
11:07

High-Throughput Metabolic Profiling for Model Refinements of Microalgae

Published on: December 4, 2021

Unraveling microalgal molecular interactions using evolutionary and structural bioinformatics.

Dimitrios Vlachakis1, Athanasia Pavlopoulou, Dorothea Kazazi

  • 1Bioinformatics & Medical Informatics Team, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, Athens 11527, Greece.

Gene
|August 1, 2013
PubMed
Summary

Microalgae are vital microorganisms that produce oxygen and consume carbon dioxide. Gene fusion analysis revealed evolutionary insights and protein structures, aiding microalgae

Keywords:
3D6,7-dimethyl-8-(1′-d-ribityl)-lumanizine6-phosphogluconate dehydrogenase6PGDHATPAdenosine triphosphateBLASTBasic Local Alignment Search ToolCO(2)COX2ACOX2BCarbon dioxideDHAPDMRLDOT1Disruptor of Telomeric silencingFra10Ac1Fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1G3PG6PDHGAPDHGene fissionGene fusionHomology modelingMEPMOEMicroalgaeMolecular Operating EnvironmentMolecular electrostatic potentialNCBINPSNVTNational Center for Biotechnology InformationNetwork Protein Sequence AnalysisNumber of atoms, Volume and TemperaturePDBProtein Data BankProtein associationRMSDRNARibonucleic acidRoot-mean-square deviationSAFESH3Software for the Analysis of Fusion EventsSrc homology 3 domainTIMThree-dimensionalTriosephosphate isomeraseTrp-AspWDcytochrome c oxidase subunit II C-terminalcytochrome c oxidase subunit II, transmembrane domaind-Glyceraldehyde 3-phosphatedihydroxyacetone phosphateglucose-6-phosphate 1-dehydrogenaseglyceraldehyde-3-phosphate dehydrogenase

More Related Videos

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Related Experiment Videos

Last Updated: May 9, 2026

High-Throughput Metabolic Profiling for Model Refinements of Microalgae
11:07

High-Throughput Metabolic Profiling for Model Refinements of Microalgae

Published on: December 4, 2021

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Area of Science:

  • * Evolutionary biology
  • * Bioinformatics
  • * Phycology

Background:

  • * Microalgae are crucial for environmental stability, producing significant atmospheric oxygen and consuming carbon dioxide.
  • * Understanding microalgal evolution and protein functions is key for their efficient utilization.

Purpose of the Study:

  • * To investigate the evolutionary history of microalgae through the analysis of protein fusion and fission events.
  • * To predict the three-dimensional structures of these proteins and identify potential interactions.
  • * To bridge the gap between ancient microalgal species evolution and modern bioinformatics.

Main Methods:

  • * Gene fusion analysis to identify key evolutionary events.
  • * 3D protein structure prediction for fused and component proteins.
  • * Bioinformatics approaches to analyze protein evolution.

Main Results:

  • * Identification of a series of five fusion/fission events in microalgal protein evolution.
  • * Prediction of 3D structures for these proteins, revealing insights into their functions.
  • * Elucidation of putative protein-protein interactions.

Conclusions:

  • * The study provides critical insights into the evolutionary history of microalgae.
  • * Predicted protein structures and interactions enhance the potential for microalgae exploitation.
  • * This research expands the microalgae knowledgebase by integrating evolutionary and bioinformatics perspectives.