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Updated: May 9, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

pRb controls estrogen receptor alpha protein stability and activity.

Isabella Caligiuri1, Giuseppe Toffoli, Antonio Giordano

  • 1Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA.

Oncotarget
|August 1, 2013
PubMed
Summary

The Retinoblastoma (pRb) tumor suppressor regulates Estrogen Receptor 1 (ESR1) protein levels. Loss of pRb decreases ESR1 expression via the proteasome pathway, revealing a novel regulatory mechanism in breast cells.

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