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[Carotid dissection associated with Ehlers-Danlos syndrome. Report of one case]

Anne-Marie Chassin-Trubert Contreras1

  • 1Servicio de Medicina Interna, Hospital San José, Santiago, Chile. annechassin@gmail.com

Revista Medica De Chile
|August 1, 2013
PubMed

Insights

Vascular Ehlers-Danlos syndrome, a collagen III defect, can cause arterial dissection and stroke. A 15-year-old patient with this condition experienced a stroke due to carotid artery dissection but responded well to antiplatelet therapy.

Area of Science:

  • Vascular biology
  • Connective tissue disorders
  • Neurology

Background:

  • Ehlers-Danlos syndrome (EDS) is a group of inherited connective tissue disorders.
  • Vascular EDS (vEDS) involves a defect in collagen type III synthesis, crucial for blood vessel integrity.
  • This defect predisposes individuals to arterial and organ rupture.

Observation:

  • A 15-year-old female with a history of EDS presented with symptoms of ischemic stroke.
  • Imaging revealed dissection of the right internal carotid artery as the cause of the stroke.
  • This case highlights a rare neurological complication in a young patient with EDS.

Findings:

  • The patient's ischemic stroke was directly linked to spontaneous carotid artery dissection.
  • Conservative management with antiplatelet agents was initiated.
  • The patient demonstrated a positive clinical response to the antiplatelet therapy.

Implications:

  • This case underscores the risk of cerebrovascular events, such as stroke, in patients with vascular EDS.
  • It emphasizes the importance of considering arterial dissection in young EDS patients presenting with neurological deficits.
  • Conservative management with antiplatelet agents may be a viable option for such cases, warranting further investigation.

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