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Hindbrain GLP-1 receptor-mediated suppression of food intake requires a PI3K-dependent decrease in phosphorylation of

Laura E Rupprecht1, Elizabeth G Mietlicki-Baase, Derek J Zimmer

  • 1Translational Neuroscience Program, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

American Journal of Physiology. Endocrinology and Metabolism
|August 1, 2013
PubMed
Summary

Glucagon-like peptide-1 receptors in the brainstem control feeding by activating PI3K and Akt pathways. This research reveals how these pathways suppress appetite, offering new insights into metabolic regulation.

Keywords:
glucagon-like peptide-1nucleus tractus solitariusobesityphosphatidylinositol-3 kinaseprotein kinase B

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