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Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
Type 1 and type 2 diabetes mellitus: are they mutually exclusive?
Aziz Fatima1, Khadija Irfan Khawaja, Saira Burney
1Endocrinology Unit and Diabetes Management Centre, Services Institute of Medical Sciences and Services Hospital, Lahore, Pakistan.
Singapore Medical Journal
|August 1, 2013
Summary
Type 1 and Type 2 diabetes mellitus (T1DM and T2DM) show overlap. Autoantibodies found in T1DM appear in some T2DM patients, while insulin resistance is seen in T1DM patients, especially those overweight.
Area of Science:
- Endocrinology
- Immunology
- Metabolic Disorders
Background:
- The distinction between type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) is becoming less clear.
- Pathogenesis of diabetes mellitus (DM) reveals potential overlap between immune-mediated DM and insulin resistance.
Purpose of the Study:
- To investigate the overlap between T1DM and T2DM.
- To test for autoantibodies typical of T1DM in T2DM patients and insulin resistance in T1DM patients.
Main Methods:
- Tested 82 T2DM and 27 T1DM patients for islet cell autoantibodies, GAD65, and IA-2.
- Calculated HOMA-IR to assess insulin resistance.
- Analyzed clinical and biochemical markers for predictive value.
Main Results:
- 12.19% of T2DM patients had beta cell autoantibodies.
- 37.03% of T1DM patients exhibited insulin resistance (HOMA-IR > 2.5).
- T1DM patients with insulin resistance had higher BMI (p=0.02). No clinical markers predicted autoantibody positivity in T2DM.
Conclusions:
- Beta cell autoantibodies are present in some insulin-resistant T2DM patients.
- Insulin resistance can occur in overweight T1DM patients.
- No specific clinical features predict autoantibody positivity in T2DM.
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