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Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration

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Relaxation by amplitude modulation: A rapid T1 measurement method.

Xiaowei Zou¹, Truman R Brown

¹Department of Biomedical Engineering, Columbia University, New York, New York, USA; Medical University of South Carolina, Charleston, South Carolina, USA.

Magnetic Resonance in Medicine

|August 1, 2013

Summary

A new method accurately measures longitudinal relaxation time (T1) using complex amplitude modulation. This technique is nearly twice as fast as existing methods, offering improved efficiency for MRI scans.

Keywords:

amplitude modulation brain longitudinal relaxation time magnetic resonance imaging neuropathology rapid measurement relaxation times

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Area of Science:

Magnetic Resonance Imaging (MRI)
Biomedical Engineering
Medical Physics

Background:

Longitudinal relaxation time (T1) is a crucial parameter in Magnetic Resonance Imaging (MRI).
Conventional T1 measurement methods can be time-consuming.
Complex amplitude modulation offers a novel approach to T1 quantification.

Purpose of the Study:

To present a novel method for measuring longitudinal relaxation time (T1) using complex amplitude modulation.
To evaluate the accuracy and reproducibility of this new T1 measurement technique.

Main Methods:

The method employs a series of inversion pulses with a binary modulation sequence.
Sequences were implemented on a Siemens 3T Trio scanner using gradient echo readout and EPI.
Validation was performed using T1 phantoms and a human volunteer, compared against the inversion recovery method.

Main Results:

T1 measurements using complex amplitude modulation demonstrated high accuracy and reproducibility in phantom and human studies.
The average scan time achieved was approximately 1.6 seconds per slice.
The method proved to be significantly faster than existing T1 measurement techniques.

Conclusions:

The presented complex amplitude modulation method offers a fast and accurate approach for T1 quantification in MRI.
This protocol is nearly twice as fast as the two fastest existing methods.
Further optimization and acceleration techniques can enhance the speed of this T1 measurement method.