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Updated: May 9, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers

Kai Hung Tiong1, Li Yen Mah, Chee-Onn Leong

  • 1School of Postgraduate Studies and Research, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia, kaihung_tiong@imu.edu.my.

Apoptosis : an International Journal on Programmed Cell Death
|August 1, 2013
PubMed

Insights

Fibroblast growth factor receptors (FGFRs) are crucial for cell growth and repair. Dysregulation of FGFR signaling contributes to various cancers, leading to the development of targeted therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Developmental Biology

Background:

  • Fibroblast growth factor receptors (FGFRs) play vital roles in cell proliferation, differentiation, development, and tissue repair.
  • Aberrant FGFR signaling pathways are implicated in numerous pathological conditions, developmental syndromes, and tumorigenesis.
  • Understanding FGFR signaling is critical for developing effective cancer treatments.

Purpose of the Study:

  • To provide a comprehensive overview of the FGFR family.
  • To elucidate the complex signaling pathways of FGFRs in tumorigenesis.
  • To review the current development and application of FGFR-targeted therapeutics for refractory human cancers.

Main Methods:

  • Literature review of scientific publications on FGFRs.
  • Analysis of FGFR signaling pathways in cancer.
  • Examination of current therapeutic strategies targeting FGFRs.

Main Results:

  • FGFRs comprise a family of receptor tyrosine kinases with diverse roles in cellular processes.
  • FGFR signaling deregulation is a common mechanism in various human cancers.
  • Targeted therapies inhibiting FGFR signaling show promise in treating specific refractory cancers.

Conclusions:

  • FGFRs are critical regulators of fundamental biological processes.
  • Dysregulated FGFR signaling drives cancer development and progression.
  • Targeting FGFRs represents a promising therapeutic strategy for refractory cancers, with ongoing development and clinical application.

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