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Updated: May 9, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema
Kristin M Burkart1, Ani Manichaikul, Jemma B Wilk
1For a full list of the authors' affiliations please see the Acknowledgements.
The European Respiratory Journal
|August 1, 2013
Summary
Researchers explored cardiovascular genes
Area of Science:
- Genetics and Respiratory Medicine
Background:
- Chronic obstructive pulmonary disease (COPD) is frequently comorbid with cardiovascular disease.
- Limited research exists on the genetic links between cardiovascular conditions and COPD.
Purpose of the Study:
- To investigate the association between cardiovascular disease-related genes and lung function in COPD.
- To identify novel genetic factors and pathways contributing to COPD pathogenesis.
Main Methods:
- Genome-wide association study (GWAS) of lung function (FEV1/FVC ratio, emphysema) in European-Americans and African-Americans.
- Replication of significant findings in independent cohorts.
- Analysis of gene expression and lipid biomarkers (HDL, APOM).
Main Results:
- Two novel single-nucleotide polymorphisms (SNPs) associated with FEV1/FVC ratio were identified, both flanking the apolipoprotein M (APOM) gene.
- APOM gene variants and expression were linked to COPD phenotypes (FEV1/FVC, emphysema).
- Higher high-density lipoprotein (HDL) cholesterol levels correlated with poorer lung function and increased emphysema.
Conclusions:
- The apolipoprotein M/HDL cholesterol pathway plays a potential role in the development of COPD and emphysema.
- Genetic variations influencing lipid metabolism may contribute to COPD pathogenesis.
- This study highlights a novel genetic link between cardiovascular health and respiratory disease.
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