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Updated: May 9, 2026
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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Factors associated with mortality in tuberculosis patients
Roya Alavi-Naini1, Ali Moghtaderi, Maliheh Metanat
1Department of Infectious Diseases, Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Summary
Anemia, smoking, and positive sputum smears significantly increase the risk of death in tuberculosis patients. Managing co-morbidities like diabetes and preventing smoking are crucial for reducing mortality in TB cases.
Area of Science:
- Infectious Diseases
- Public Health
- Epidemiology
Background:
- Tuberculosis (TB) remains a leading cause of global morbidity and mortality.
- Identifying predictors of mortality in TB patients is essential for improving patient outcomes.
- This study focused on a high-prevalence region in Iran to understand in-hospital TB mortality factors.
Purpose of the Study:
- To identify common risk factors associated with death in patients diagnosed with tuberculosis (TB) during hospitalization.
- To provide insights for predicting prognosis and reducing mortality among TB patients in a high-incidence area.
Main Methods:
- A retrospective study evaluated 715 adult pulmonary TB patients (≥15 years) from February 2002 to February 2011.
- Data on smoking, HIV infection, drug use, lung cancer, drug hepatitis, diabetes mellitus, previous TB, anemia, and sputum smear results were analyzed.
- Univariate and multiple logistic regression analyses were employed to determine factors linked to mortality.
Main Results:
- Anemia (AOR: 19.8), positive sputum smear (AOR: 13.4), smoking (AOR: 12.9), and drug hepatitis (AOR: 12.3) were identified as major risk factors for death.
- Diabetes mellitus (AOR: 9.7), drug use (AOR: 7.8), and a history of previous TB (AOR: 6.8) also significantly increased mortality risk.
- Of 715 patients, 75 (10.5%) died during TB treatment.
Conclusions:
- Close monitoring of co-morbidities such as diabetes mellitus and anemia is vital for reducing TB-related deaths.
- Preventive strategies targeting smoking and drug addiction are crucial for decreasing mortality rates.
- Regular follow-up for patients with a history of previous TB treatment is recommended to improve outcomes.
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