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Updated: May 9, 2026

Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method
Published on: May 12, 2023
[The optimation of extraction technology of chuanxiong and xiangfu compatibility by SFE-CO2]
1Pharmaceutical Preparation Section, First Affiliated Hospital of Zhongshan University, Guangzhou 510700, China. linqlinj@126.com
Objective:
To optimize the extraction conditions of Chuanxiong and Xiangfu compatibility by supercritical CO2 and control the quality of the extract.
Methods:
The orthogonal design experiments were used to select the optimal conditions and the factors were extraction pressure, extraction temperature, extraction time and flow rate of CO2. The extraction rate was used as inspection index. The contents of alpha-cyperolone and butenyl were detected by HPLC.
Results:
The optimal conditions were as follows: extraction pressure 25 Mpa, extraction temperature 45 degrees C, extraction time 2 h, flow rate of CO2 20 Kg/h. The average content of alpha-cyperolone, butenyl was 3.26%, 1.50% respectively.
Conclusion:
The method of supercritical CO2 extraction is reliable and feasible and can be used in industry. The quality of the extract is stable and controlled.
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