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Peptide sharing between Bordetella pertussis proteome and human sudden death proteins: a hypothesis for a causal link
Giovanni Capone1, Darja Kanduc
1Department of Biosciences, Biotechnologies & Biopharmaceutics, University of Bari, Bari, Italy.
Aim:
To explore the molecular basis of the relationship between Bordetella pertussis infection and sudden death.
Methods:
B. pertussis proteins were analyzed for amino acid sequence identity to a set of 67 human proteins that, when altered, have been associated with sudden death.
Results:
More than 82,000 pentapeptides are shared between B. pertussis proteins and sudden death-associated antigens.
Conclusion:
Results suggest that a possible link between B. pertussis infection and sudden death might be represented by potential immunological cross-reactions occurring between B. pertussis proteins and human proteins associated to sudden death.
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