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Photo responsive monoolein cubic phase containing coumarin-Tween 20 conjugates
1College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Kangwon-do, Korea.
This study created a photo-responsive monoolein cubic phase using a coumarin-Tween 20 conjugate. UV light cross-links the conjugate, stabilizing the cubic phase and reducing drug release.
Area of Science:
- Materials Science
- Biotechnology
- Physical Chemistry
Background:
- Monoolein (MO) cubic phases are advanced drug delivery systems.
- Controlling drug release from cubic phases is crucial for therapeutic efficacy.
- Photo-responsive materials offer tunable release mechanisms.
Purpose of the Study:
- To develop a photo-responsive monoolein cubic phase.
- To investigate the effect of UV irradiation on the cubic phase integrity and drug release.
- To functionalize Tween 20 with coumarin for photo-responsiveness.
Main Methods:
- Synthesis of 7-chlorocarbonylmethoxycoumarin and conjugation to Tween 20.
- Formation of monoolein cubic phase incorporating the coumarin-Tween 20 conjugate.
- Incorporation of 5(6)-carboxyfluorescein (CF) as a model drug.
- UV irradiation (254 nm and/or 365 nm) and analysis of cubic phase stability and CF release.
Main Results:
- Successful synthesis of coumarin-Tween 20 conjugate with a 1:1 molar ratio.
- Monoolein cubic phase remained stable under UV irradiation.
- UV irradiation caused a slight reduction (1.27%–2.69%) in MO double bonds.
- CF release was suppressed under UV irradiation due to conjugate cross-linking.
Conclusions:
- The coumarin-Tween 20 conjugate effectively imparts photo-responsiveness to the monoolein cubic phase.
- UV-induced cross-linking of the conjugate stabilizes the cubic phase structure.
- This system demonstrates potential for controlled drug delivery applications.
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