Related Experiment Video

Updated: May 7, 2026

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

41.0K

Subclinical left ventricular dysfunction and silent cerebrovascular disease: the Cardiovascular Abnormalities and

Cesare Russo1, Zhezhen Jin, Shunichi Homma

  • 1Department of Medicine, Columbia University, New York, NY 10032, USA.

Circulation
|August 2, 2013
PubMed

Insights

Global longitudinal strain (GLS) detects subclinical brain disease, including silent brain infarcts, in the general population. This cardiac measure offers insights into cerebrovascular risk beyond traditional left ventricular ejection fraction (LVEF) assessment.

Area of Science:

  • Cardiology
  • Neurology
  • Medical Imaging

Background:

  • Subclinical cerebrovascular lesions like silent brain infarcts (SBIs) and white matter hyperintensities are linked to stroke and cognitive decline.
  • Left ventricular ejection fraction (LVEF) predicts stroke in heart failure but its relation to subclinical brain disease in the general population is unclear.
  • Left ventricular global longitudinal strain (GLS) can identify early cardiac dysfunction, even with normal LVEF.

Purpose of the Study:

  • To investigate the association between LVEF, GLS, and subclinical brain disease in a community-based cohort.
  • To determine if GLS provides additional information on cerebrovascular risk compared to LVEF.

Main Methods:

  • Echocardiography (2D and speckle-tracking) assessed LVEF and GLS in 439 participants without prior stroke or cardiac disease.
  • Brain MRI evaluated for SBIs and white matter hyperintensities.
  • Multivariate analysis examined the relationship between cardiac measures and brain lesions.

Main Results:

  • Lower GLS, but not LVEF, was significantly associated with the presence of SBIs.
  • Reduced GLS independently predicted SBIs (OR 1.18 per unit decrease, P<0.01).
  • Lower GLS correlated with greater white matter hyperintensity volume, while LVEF did not.

Conclusions:

  • Lower GLS is independently associated with subclinical brain disease in a general community cohort.
  • GLS offers valuable information regarding cerebrovascular risk beyond LVEF.
  • GLS may serve as a novel biomarker for identifying individuals at risk for cerebrovascular events.
Abstract

Keywords:
brain infarctionechocardiographyglobal longitudinal strainmagnetic resonance imagingspeckle-trackingventricular ejection fractionwhite matter diseases

More Related Videos

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

13.9K
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

2.6K

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
979
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
632
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
502
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
961
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
593
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
31