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Updated: May 9, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Recent advances in stereoselective bromofunctionalization of alkenes using N-bromoamide reagents
Chong Kiat Tan1, Ying-Yeung Yeung
1Department of Chemistry, NUS, 3 Science Drive 3, 11754, Singapore.
Abstract:
Bromination reactions have been made a lot more convenient since the invention of N-bromoamide reagents. These reagents are more easily handled when compared to molecular bromine. In comparison to other halogens, brominating reagents sit in between chlorine and iodine on the reactivity scale, giving them an advantage in some cases. Recently, several important advances in enantioselective bromofunctionalization of alkenes using such reagents have been reported. This article will highlight the challenges and methods to surmount these problems. In addition, this article will also show the use of N-bromoamide reagents in expanding the scope of diastereoselective bromofunctionalization of alkenes. Examples include bromine initiated cyclic ether cascades and novel multicomponent reactions (MCRs).
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