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Management of methomyl poisoning
J Martinez-Chuecos1, F Molinero-Somolinos, J Solé-Violàn
1Intensive Care Unit, Hospital Nuestra Señora de Candelaria, Tenerife, Spain.
Human & Experimental Toxicology
|July 1, 1990
Summary
Methomyl poisoning in patients presented with mild cholinergic symptoms and normal or slightly reduced cholinesterase activity. Prompt treatment with decontamination, activated charcoal, and low-dose atropine led to full recovery within 48 hours, indicating methomyl poisoning is generally not severe.
Area of Science:
- Toxicology
- Clinical Medicine
- Pharmacology
Background:
- Methomyl is a carbamate insecticide that can cause poisoning.
- Cholinergic symptoms are characteristic of insecticide poisoning.
- Limited data exists on the clinical presentation and management of methomyl poisoning.
Purpose of the Study:
- To describe the clinical features, treatment, and outcomes of patients with methomyl poisoning.
- To evaluate the severity and potential complications of methomyl poisoning.
- To determine the appropriate management strategy for methomyl poisoning.
Main Methods:
- Retrospective case series of eleven patients admitted to the ICU for methomyl poisoning.
- Clinical data collection including symptoms, plasma cholinesterase activity, and treatment administered.
- Follow-up assessment one month post-discharge to evaluate for delayed complications.
Main Results:
- Patients exhibited mild cholinergic symptoms, miosis, and normal or moderately reduced plasma cholinesterase activity.
- No serious complications were observed during the acute phase or at one-month follow-up.
- All patients recovered within 24-48 hours following gastric lavage/skin washing, activated charcoal, and low-dose atropine.
Conclusions:
- Methomyl poisoning typically presents with less severe cholinergic symptoms compared to organophosphates.
- With appropriate supportive care and symptomatic treatment, methomyl poisoning has a favorable prognosis.
- Small doses of atropine are generally sufficient for managing the symptoms of methomyl poisoning.