Related Experiment Video
Updated: May 9, 2026

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
Published on: November 2, 2019
Mobilization of fluids in large volumetric reductions during intensive treatment of leg lymphedema
J M Pereira De Godoy1, P A Franco Brigidio, S X Salles Cunha
1Cardiology and Cardiovascular Surgery Department of the Medicine School in São José do Rio Preto FAMERP, Brazil. godoyjmp@gmail.com
Aim:
The aim of the current study was to evaluate fluid mobilization during the intensive treatment of leg lymphedema.
Methods:
The mobilization of intracellular and extracellular fluids in the lower and upper extremities and trunk was evaluated with the intensive treatment of leg lymphedema in a prospective study. Mobilization of fluids was assessed by bioelectrical impedance using the InBody S10 device in ten patients with leg lymphedema, regardless of the cause. Treatment consisted of six to eight hours per day of Manual Lymphatic Therapy (Godoy & Godoy technique), Mechanical Lymphatic Therapy (RAGodoy device®) and a non-elastic cotton-polyester stocking.
Results And Conclusion:
A significant reduction in total water was observed for the lymphedematous limb, but with an increase in intracellular water of from 59% to 61%. Additionally, total water increases were observed in the limbs without lymphedema and in the trunk. There was an increase in total intracellular water of the extremities and trunk, but without any change in the extracellular water. In high-volume reductions during lymphedema treatment, fluids are displaced from the lymphedematous limb to extremities without lymphedema and to the trunk.
Related Concept Videos
Lymphatic Vessels and Lymph Transport
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Fluid Movement Between Compartments
Venous Thrombosis IV: Nursing Management
Venous Thrombosis III: Interprofessional Care
Nephrotic Syndrome III : Nursing Management
