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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

A new echocardiographic parameter of arterial stiffness in end-stage renal disease

M Sahin1, H Simsek, A Akyol

  • 1Faculty of Medicine, Department of Cardiology, Yuzuncu Yil University, Van, Turkey, drmusasahin@gmail.com.

Herz
|August 2, 2013
PubMed

Insights

Arterial stiffness, a key indicator of cardiovascular risk in end-stage renal disease (ESRD) patients, can be practically assessed using aortic propagation velocity (APV). This echocardiographic method offers a valuable tool for identifying arterial stiffness in ESRD.

Area of Science:

  • Cardiology
  • Nephrology
  • Vascular Biology

Background:

  • Cardiovascular disease (CVD) is the primary cause of mortality in end-stage renal disease (ESRD) patients.
  • Arterial stiffness is a significant predictor of mortality in ESRD.
  • Current methods for measuring arterial stiffness are time-consuming and impractical for routine clinical use.

Purpose of the Study:

  • To evaluate the utility of aortic propagation velocity (APV) as a practical method for assessing arterial stiffness in ESRD patients.
  • To compare arterial stiffness parameters between ESRD patients and healthy controls.

Main Methods:

  • The study included 50 ESRD patients (23 hemodialysis, 27 peritoneal dialysis) and 70 controls.
  • Measurements included aortofemoral pulse wave velocity (PWV), carotid intima-media thickness (CIMT), and aortic propagation velocity (APV).

Main Results:

  • ESRD patients exhibited significantly lower APV and higher PWV and CIMT compared to controls (p < 0.01).
  • APV showed strong correlations with CIMT (r=-0.769) and PWV (r=-0.682) (p < 0.001).
  • No significant differences in APV or PWV were observed between hemodialysis and peritoneal dialysis groups.

Conclusions:

  • Arterial stiffness, indicated by APV, is a crucial marker of atherosclerosis and aging in ESRD.
  • APV measurement is a simple, practical echocardiographic technique for identifying arterial stiffness in ESRD patients.
Abstract

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