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Related Concept Videos

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...

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Related Experiment Video

Updated: May 9, 2026

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70
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Published on: August 9, 2019

Has the circulating permeability factor in primary FSGS been found?

J Ashley Jefferson1, Stuart J Shankland

  • 1Department of Medicine, University of Washington, Seattle, Washington 98195, USA. jashleyj@uw.edu

Kidney International
|August 2, 2013
PubMed
Summary
This summary is machine-generated.

Soluble urokinase-type plasminogen activator receptor (suPAR) may be a biomarker for primary focal segmental glomerulosclerosis (FSGS). Further research could reveal new diagnostic and therapeutic strategies for this kidney disease.

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Published on: August 19, 2020

Area of Science:

  • Nephrology
  • Molecular Biology

Background:

  • Primary focal segmental glomerulosclerosis (FSGS) pathogenesis is linked to a circulating permeability factor.
  • The soluble urokinase-type plasminogen activator receptor (suPAR) is investigated for its potential role.

Purpose of the Study:

  • To explore the role of suPAR as a biomarker and potential factor in primary FSGS.
  • To investigate potential diagnostic and therapeutic strategies for FSGS based on suPAR.

Main Methods:

  • Review of evidence from animal models.
  • Analysis of patient cohorts with primary FSGS.

Main Results:

  • Evidence suggests suPAR's involvement in primary FSGS.
  • suPAR is identified as a potential biomarker for FSGS.

Conclusions:

  • suPAR may serve as a biomarker in primary FSGS.
  • Findings may inform new diagnostic and therapeutic approaches for FSGS.
  • Understanding suPAR's role could elucidate podocyte dysfunction in FSGS.