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Updated: May 9, 2026
Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
Published on: August 10, 2015
In vivo imaging of disease-modified glomerular extracellular matrix in renal disease
1Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Chaudhary and colleagues describe an in vivo imaging technique for detecting altered glomerular extracellular matrix after development of glomerulonephritis. Using fluorochrome-labeled Fab fragments of the human monoclonal antibody F1.1 against the NC1 domain of the α3 chain of collagen type IV, in vivo binding is shown in glomeruli from mice with nephritis, while the activation of complement and Fc receptors is prevented. This novel method might allow rapid in vivo detection of renal disease.
Chaudhary and colleagues describe an in vivo imaging technique for detecting altered glomerular extracellular matrix after development of glomerulonephritis. Using fluorochrome-labeled Fab fragments of the human monoclonal antibody F1.1 against the NC1 domain of the α3 chain of collagen type IV, in vivo binding is shown in glomeruli from mice with nephritis, while the activation of complement and Fc receptors is prevented. This novel method might allow rapid in vivo detection of renal disease.
