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Published on: May 20, 2021
Leukodepletion for patients undergoing heart valve surgery
Sally Spencer1, Augustine Tang, Espeed Khoshbin
1Faculty of Health and Medicine, Lancaster University, Lancaster, UK. s.spencer1@lancaster.ac.uk.
The Cochrane Database of Systematic Reviews
|August 2, 2013
Summary
Leukodepletion filters show no significant benefit in heart valve surgery patients. More high-quality trials are needed to determine their effectiveness and impact on clinical outcomes.
Area of Science:
- Cardiovascular Surgery
- Medical Device Technology
- Patient Safety
Background:
- Leukodepletion shows potential benefits in coronary artery surgery.
- Effectiveness of leukodepletion in higher-risk heart valve surgery patients is unclear.
Purpose of the Study:
- Assess leukodepletion's effects on clinical, patient-reported, and economic outcomes in heart valve surgery.
- Evaluate beneficial and harmful effects of leukodepletion filters.
Main Methods:
- Systematic review of randomized controlled trials comparing leukodepleting and standard arterial line filters.
- Searched multiple databases (CENTRAL, MEDLINE, EMBASE, etc.) and clinical trial registries.
- Extracted data on mortality, length of stay, adverse events, kidney injury, and quality of life.
Main Results:
- Only one small study (24 participants) provided usable data.
- No significant differences observed in ICU or hospital length of stay between filter types.
- Insufficient data for meta-analysis or sensitivity analysis.
Conclusions:
- Current evidence is insufficient to guide clinical practice changes for leukodepletion in heart valve surgery.
- A forthcoming NIHR-funded feasibility study (ROLO trial) is expected to provide significant new data.
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