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Lipid pools as photolabile "protecting groups": design of light-activatable bioagents
Luong T Nguyen1, Nathan P Oien, Nancy L Allbritton
1Department of Biomedical Engineering, Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA).
Angewandte Chemie (International Ed. in English)
|August 2, 2013
Abstract:
Inactive in the membrane: Lipidated light-responsive constructs that sequester bioagents (R, see scheme) to the membranes of organelles and cells have been constructed. When membrane-bound, the bioagent is not susceptible to processing by its biological target. Photolysis releases the bioagent from its membrane anchor and thereby renders it biologically active.
