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Updated: May 9, 2026
10:12
Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
Published on: September 11, 2019
Human immunodeficiency virus and liver disease forum 2012
Kenneth E Sherman1, David Thomas, Raymond T Chung
1Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH.
Hepatology (Baltimore, Md.)
|August 2, 2013
Summary
Human immunodeficiency virus (HIV) patients face high rates of liver disease due to viral coinfections and HIV itself. Management strategies must address complex factors like drug use and socioeconomic status for better outcomes.
Area of Science:
- Hepatology and Virology
- Infectious Diseases and Immunology
Background:
- Over 1.1 million people in the US have HIV, often with co-occurring liver disease.
- Liver disease in HIV patients stems from viral hepatitis, drug toxicity, fatty liver, and HIV's direct/indirect effects.
- HIV infection impacts the liver through bacterial translocation, immune activation, and altered cytokine profiles.
Framework:
- Direct-acting antivirals offer new hope for Hepatitis C Virus (HCV) treatment.
- Challenges remain with direct-acting antivirals, including toxicity and drug interactions.
- Emerging concerns include acute HCV, undetected Hepatitis D, and Hepatitis E infections.
Implementation:
- Antiretroviral therapies may contribute to liver injury and portal hypertension.
- Integrated care models are crucial for managing liver disease in HIV populations.
- Addressing co-factors like injection drug use, alcohol consumption, and socioeconomic status is vital.
Implications:
- Improved liver disease management is essential for reducing mortality in HIV patients.
- Future research should focus on novel therapeutic approaches and preventative strategies.
- Multifaceted interventions are needed to address the complex health needs of this population.
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