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Modulation of inflammation by interleukin-27.
11.University of Michigan Medical School, 1301 Catherine Rd., Ann Arbor, MI 48109-5602, USA. pward@umich.edu.
Journal of Leukocyte Biology
|August 2, 2013
Summary
Interleukin-27 (IL-27) is a key cytokine regulating immune responses, particularly in T cells. While often seen as anti-inflammatory, recent findings reveal IL-27 can also promote inflammation in certain contexts.
Area of Science:
- Immunology
- Cytokine Biology
- Inflammation Research
Background:
- Interleukin-27 (IL-27) is a heterodimeric cytokine, part of the IL-12 family, crucial for immune regulation.
- Antigen-presenting cells (APCs) are primary sources of IL-27 upon activation by microbial products or interferons.
- IL-27's role in immunity, particularly in infectious and autoimmune diseases, is under extensive investigation.
Purpose of the Study:
- To review current knowledge on IL-27's implications in disease pathogenesis.
- To explore conflicting evidence regarding IL-27's pro- and anti-inflammatory roles.
- To highlight recent advances in understanding IL-27's interactions with other immune pathways.
Main Methods:
- Analysis of experimental studies using genetically modified mice (IL-27RA-/-, EBI3-/-, p28-/-).
- Review of studies involving bioengineered IL-27/IL-27RA homologs.
- Inclusion of observational data from human patients with inflammatory diseases.
Main Results:
- IL-27 plays a critical role in regulating T cell responses.
- Evidence suggests IL-27 can suppress inflammation in some contexts.
- Contrasting findings indicate IL-27 may promote inflammation in other settings.
- New insights into IL-27 interactions with complement system components.
Conclusions:
- IL-27 is a vital immunoregulatory cytokine with significant impact on T cells.
- The precise role of IL-27 in inflammation remains complex and context-dependent.
- Further research is needed to fully elucidate IL-27's dual function in immune responses.
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