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Quantification of Visual Feature Selectivity of the Optokinetic Reflex in Mice

Quantification of Visual Feature Selectivity of the Optokinetic Reflex in Mice

Published on: June 23, 2023

Orientation-selective responses in the mouse lateral geniculate nucleus.

Xinyu Zhao¹, Hui Chen, Xiaorong Liu

¹Department of Neurobiology, and Interdepartmental Neuroscience Program, Northwestern University, Evanston, Illinois 60208, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|August 2, 2013

Summary

Mouse dorsal lateral geniculate nucleus (dLGN) cells show significant orientation selectivity, originating from the retina, not cortical feedback. This finding suggests a crucial role for the dLGN in early visual processing.

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Published on: June 13, 2019

Area of Science:

Neuroscience
Visual System
Sensory Processing

Background:

The dorsal lateral geniculate nucleus (dLGN) is a key relay for visual information from the retina to the cortex.
Understanding the properties of dLGN neurons is crucial for comprehending visual processing.
The origin of orientation selectivity in the dLGN has been a subject of investigation.

Purpose of the Study:

To investigate the prevalence and characteristics of orientation selectivity in the mouse dLGN.
To determine whether orientation selectivity in the dLGN is influenced by cortical feedback.
To explore the retinal contribution to dLGN orientation selectivity.

Main Methods:

Extracellular recordings were performed in the dLGN of anesthetized and awake mice.
Pharmacological silencing of the visual cortex was used to assess feedback.
Retinal ganglion cells were studied in vitro using multielectrode arrays.
Orientation tuning was analyzed across different stimulus contrasts and compared with other visual structures.

Main Results:

A high proportion of dLGN cells exhibited orientation selectivity.
Orientation selectivity persisted even when cortical feedback was blocked.
Orientation selectivity was observed in dLGN cells with both elongated and circular receptive fields.
Orientation-selective retinal ganglion cells were identified.
dLGN orientation tuning was largely contrast-invariant and explained by a feedforward model.
Orientation selectivity was prominent in the dLGN, similar to the superior colliculus, but less than in the visual cortex.

Conclusions:

The mouse dLGN possesses significant intrinsic orientation selectivity, largely driven by retinal inputs.
Cortical feedback is not the primary source of orientation selectivity in the dLGN.
The dLGN plays a more substantial role in early visual feature extraction than previously appreciated.