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Cardiac condition in young chagasic women

O Lassen1, G Dotto, S Ojeda

  • 1Semiology Department UHMI 3, Chagas and Hypertension Office, Cordoba Hospital, Argentine.

Journal of Medicine and Life
|August 2, 2013
PubMed

Insights

Chagas disease accelerates cardiac dysfunction in young women, independent of other risks. Genetic variations in Mn-SOD may influence disease progression in these patients.

Area of Science:

  • Genetics
  • Cardiology
  • Infectious Diseases

Background:

  • Chagas disease, caused by Trypanosoma cruzi, often leads to asymptomatic cardiomyopathy.
  • Factors driving chronic myocardial damage in Chagas disease remain unclear.

Observation:

  • This study investigated single nucleotide polymorphisms (SNPs) and clinical symptoms in chagasic and non-chagasic women.
  • Genetic analysis included Mn-SOD (Ala-9Val, Ile58Thr), endothelin-1 (ET-1), and endothelin receptor A (ETA) polymorphisms.
  • Clinical assessments included biochemical profiles, X-rays, ECGs, and echocardiography (EchoCG).

Findings:

  • A significant association was found in Mn-SOD Ile58Thr gene frequencies between chagasic and non-chagasic groups.
  • Young chagasic women exhibited higher rates of X-ray and ECG abnormalities and severe heart failure symptoms (NYHA class II-III).
  • Young chagasic patients had a nearly sixfold increased likelihood of abnormal echocardiograms (OR=5.87).

Implications:

  • Trypanosoma cruzi infection accelerates cardiac function decline in young women, overriding estrogen's protective effects.
  • Genetic factors, specifically Mn-SOD Ile58Thr, may play a role in Chagas disease cardiomyopathy development.
  • Early identification and monitoring of cardiac changes in young women with Chagas disease are crucial.
Abstract

Keywords:
EchoCG alterationschagasic diseasepremenopausal women

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