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08:20
Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
Dental caries vaccine - a possible option?
Shanmugam Kt1, Masthan Kmk, Balachander N
1Reader, Department of Dentistry.
Journal of Clinical and Diagnostic Research : JCDR
|August 2, 2013
Summary
Dental caries, a widespread microbial tooth decay, requires better public health strategies. Immunological interventions targeting Streptococcus mutans show promise in preventing this common disease.
Area of Science:
- Dentistry
- Microbiology
- Immunology
Background:
- Dental caries is a prevalent, multifactorial microbial disease affecting calcified tooth tissues globally.
- High prevalence rates are reported in India, the U.S., Brazil, and China, necessitating improved public health interventions.
- Mutans streptococci are key microorganisms implicated in the etiology of dental caries.
Purpose of the Study:
- To explore the potential of immunological interventions in combating dental caries.
- To investigate the role of mucosal immune responses to Streptococcus mutans in caries pathogenesis.
Main Methods:
- Review of preclinical studies on immunological interventions for dental caries.
- Analysis of clinical trials assessing mucosal immune responses to Streptococcus mutans antigens.
Main Results:
- Preclinical studies indicate that immunological interventions can interrupt the progression of dental caries.
- Clinical trials suggest that a mucosal immune response to Streptococcus mutans influences caries pathogenesis.
Conclusions:
- Immunological approaches, particularly a dental caries vaccine, hold potential for reducing disease reemergence.
- Targeted vaccination strategies in appropriate individuals could be effective public health measures against dental caries.
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