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Updated: May 9, 2026

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
Published on: June 12, 2021
Primary percutaneous coronary intervention for ST elevation myocardial infarction complicated by cardiogenic shock
Ayaz Hussain Shaikh1, Bashir Hanif, Asad Pathan
1Tabba Heart Institute, Karachi, Pakistan. ahsdr1977@yahoo.com
Insights
Primary percutaneous coronary intervention improves outcomes for ST-elevation myocardial infarction with cardiogenic shock. Key predictors of in-hospital mortality include advanced age, diabetes, and reduced left ventricular ejection fraction.
Area of Science:
- Cardiology
- Interventional Cardiology
- Critical Care Medicine
Background:
- ST-elevation myocardial infarction (STEMI) complicated by cardiogenic shock has high mortality.
- Primary percutaneous coronary intervention (PCI) is a key reperfusion strategy.
Purpose of the Study:
- To evaluate the outcomes of primary PCI in STEMI patients with cardiogenic shock.
- To identify predictors of in-hospital mortality in this high-risk population.
Main Methods:
- Retrospective review of 56 STEMI patients with cardiogenic shock treated with primary PCI.
- Data collected from January 2009 to June 2011 at a private-sector cardiac institute.
- In-hospital mortality and its predictors were analyzed using multivariate logistic regression.
Main Results:
- In-hospital mortality was 46%.
- Independent predictors of mortality included age > 60 years, diabetes, and left ventricular ejection fraction < 40%.
- Many patients required ventilatory support (59%) and intra-aortic balloon pump (54%).
Conclusions:
- Primary PCI is a viable reperfusion strategy for STEMI with cardiogenic shock.
- Aggressive management is crucial to improve clinical outcomes in these critically ill patients.
- Identifying and managing risk factors like age, diabetes, and LV dysfunction is essential.
Objective:
To determine the outcomes of primary percutaneous coronary intervention for ST elevation myocardial infarction complicated by cardiogenic shock.
Methods:
The retrospective study was conducted at the Tabba Heart Institute, a private-sector facility in Karachi. It reviewed the medical records of 56 consecutive patients between January 2009 and June 2011 with acute ST elevation myocardial infarction complicated by cardiogenic shock and subjected to primary percutaneous coronary intervention. The primary end point was in-hospital mortality and its predictors. SPSS 14 was used for statistical analysis.
Results:
The mean age of the study patients was 63 +/- 11.7 years; 38 (68%) were male; 32 (57%) were hypertensive; and 39 (69%) were diabetic. Most infarcts were anterior in location (n = 36; 64%). Besides, 33 (59%) required ventilatory support. Intra-aortic balloon pump was placed in 30 (54%), and 33 (59%) patients had multivessel coronary artery disease. In-hospital mortality occurred in 26 (46%). Multivariate logistic regression analysis showed that age > 60 years (p < 0.05), diabetes (p < 0.01) and left ventricular ejection fraction < 40% (p < 0.01) were independent predictors of in-hospital mortality.
Conclusions:
Results emphasise the need of aggressive management of patients with cardiogenic shock utilising primary percutaneous coronary intervention as a reperfusion strategy to improve clinical outcomes.
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