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Indomethacin nanoparticles for applications in liquid ocular formulations
Velichka Y Andonova1, George S Georgiev, Ventsislava T Georgieva
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University, Plovdiv. andonova_v@abv.bg
Folia Medica
|August 3, 2013
Summary
Optimized dialysis time for poly(vinyl acetate) nanoparticles ensures effective indomethacin incorporation and release for ophthalmic drug delivery. This method removes residual monomer and initiator, maintaining therapeutic drug concentrations.
Area of Science:
- Polymer science and nanotechnology
- Ocular drug delivery systems
- Pharmaceutical formulation
Background:
- Polymeric nanocarriers show promise for treating eye disorders via controlled drug release.
- Effective drug delivery relies on polymer choice, inclusion methods, and process conditions.
Purpose of the Study:
- To create poly(vinyl acetate) nanoparticles with incorporated indomethacin.
- To evaluate how dialysis time affects indomethacin incorporation and release kinetics.
- To formulate these nanoparticles for ophthalmic applications.
Main Methods:
- Poly(vinyl acetate) nanoparticles with indomethacin were synthesized using emulsion radical polymerization without emulsifiers.
- Latexes underwent dialysis for 6, 9, 18, or 23 hours to remove residual monomer and ammonium persulfate initiator.
- Nanoparticle structure was analyzed using electron microscopy, spectroscopy, and thermal analysis; indomethacin release was monitored via UV spectroscopy.
Main Results:
- Poly(vinyl acetate) nanocarriers demonstrated delayed indomethacin release without chemical interaction between drug and polymer.
- A 9-hour dialysis effectively removed residual vinyl acetate and initiator, preserving therapeutic indomethacin concentrations.
Conclusions:
- A dialysis duration between 6 and 9 hours is optimal for removing residual monomer and initiator.
- This optimized process yields indomethacin nanoparticles suitable for liquid ocular formulations.
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