Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 9, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

Application of deep sequence technology in hepatology.

Masashi Ninomiya¹, Yoshiyuki Ueno, Tooru Shimosegawa

¹Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai.

Hepatology Research : the Official Journal of the Japan Society of Hepatology

|August 3, 2013

Summary

Deep sequencing, or next-generation sequencing (NGS), generates vast amounts of biomedical data. This review covers current NGS systems and their applications in hepatology research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical Significance of Anti-Atezolizumab Antibodies in Patients With Unresectable Hepatocellular Carcinoma Treated With Atezolizumab Plus Bevacizumab.

Hepatology research : the official journal of the Japan Society of Hepatology·2026

Same author

Association between deletions in the preS1/2 region of the hepatitis B virus genome and persistently abnormal ALT levels in patients with chronic hepatitis B treated with nucleos(t)ide analogs.

Archives of virology·2025

Same author

The interferon-inducible MxB large GTPase attenuates hepatitis B virus replication by activating the RIG-I innate immunity signaling pathway.

Scientific reports·2025

Same author

A New Model to Predict Survival Time in Patients With Hepatocellular Carcinoma With BCLC Advanced Stage.

Cancer medicine·2025

Same author

Giant hepatic hemangioma in a Japanese adult patient reduced by sirolimus therapy.

Clinical journal of gastroenterology·2025

Same author

Identification of low-molecular compounds that inhibit envelope formation of hepatitis B virus.

Scientific reports·2025

Area of Science:

Biomedicine
Genomics
Hepatology

Background:

Deep sequencing technologies offer over 100x more data than traditional Sanger sequencing.
Next-generation sequencing (NGS) utilizes parallel processes for simultaneous, high-volume sequence read production.

Purpose of the Study:

To review current deep sequencing systems.
To discuss the application of advanced sequencing technologies in hepatology.

Main Methods:

Review of current deep sequencing technologies.
Analysis of next-generation sequencing (NGS) systems.
Exploration of NGS applications in hepatology.

Main Results:

NGS systems have rapidly advanced since the introduction of the GS20.

Keywords:

deep sequencing technology next-generation sequencing pyrosequencing sequencing-by-synthesis

More Related Videos

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

Application of Live Mitochondria Staining in Cell-Sorting to Purify Hepatocytes Derived from Human Induced Pluripotent Stem Cells

Application of Live Mitochondria Staining in Cell-Sorting to Purify Hepatocytes Derived from Human Induced Pluripotent Stem Cells

Published on: December 1, 2023

Related Experiment Videos

Last Updated: May 9, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

Application of Live Mitochondria Staining in Cell-Sorting to Purify Hepatocytes Derived from Human Induced Pluripotent Stem Cells

Application of Live Mitochondria Staining in Cell-Sorting to Purify Hepatocytes Derived from Human Induced Pluripotent Stem Cells

Published on: December 1, 2023

Intense competition drives continuous innovation in sequencing technology.

Advanced sequencing technologies present new opportunities in biomedical research.

Conclusions:

Deep sequencing, particularly NGS, is revolutionizing data generation in biomedicine.
The review highlights the growing importance and application of NGS in the field of hepatology.