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Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Goiter01:27

Goiter

Goiter refers to an abnormal enlargement of the thyroid gland that may appear as a diffuse goiter (uniform enlargement) or nodular (single or multiple nodules). Functionally, it is classified as nontoxic (normal/low hormone levels) or toxic (excess hormone production).PathophysiologyDiffuse thyroid enlargement typically results from prolonged stimulation by thyroid-stimulating hormone (TSH) or TSH-like agents, commonly seen in hypothyroidism or iodine deficiency. In contrast, in hyperthyroid...
Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

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Related Experiment Video

Updated: May 9, 2026

Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species
12:53

Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species

Published on: May 19, 2018

Enlarged neck lymph nodes in children.

Karthik Rajasekaran1, Paul Krakovitz

  • 1Head and Neck Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Pediatric Clinics of North America
|August 3, 2013
PubMed
Summary

Pediatric cervical lymphadenopathy presents diagnostic challenges. Understanding its diverse causes guides appropriate workup and management strategies for affected children.

Area of Science:

  • Pediatric medicine
  • Otolaryngology
  • Infectious diseases

Background:

  • Cervical lymphadenopathy is common in children, with varied etiologies.
  • Accurate diagnosis is crucial for effective patient management.
  • A systematic approach aids in differentiating causes.

Purpose of the Study:

  • To review common causes of pediatric cervical lymphadenopathy.
  • To present a methodical diagnostic and management approach.

Main Methods:

  • Literature review of pediatric cervical lymphadenopathy.
  • Clinical case analysis.
  • Diagnostic pathway evaluation.

Main Results:

  • Common causes include infections, inflammatory conditions, and malignancies.
Keywords:
Cervical adenopathyEnlarged lymph nodesLymphadenopathyNeck massPediatric lymph nodes

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Modified Radical Neck Dissection for Cervical Metastasis
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Modified Radical Neck Dissection for Cervical Metastasis

Published on: February 20, 2026

Related Experiment Videos

Last Updated: May 9, 2026

Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species
12:53

Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species

Published on: May 19, 2018

Modified Radical Neck Dissection for Cervical Metastasis
06:05

Modified Radical Neck Dissection for Cervical Metastasis

Published on: February 20, 2026

  • History, physical examination, and diagnostic studies are key.
  • Imaging modalities aid in differential diagnosis.
  • Conclusions:

    • A structured approach improves diagnostic accuracy for pediatric cervical lymphadenopathy.
    • Timely and appropriate management is essential for favorable outcomes.