Related Experiment Video

Updated: May 9, 2026

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Chronic rhinosinusitis in children

Austin S Rose1, Brian D Thorp, Adam M Zanation

  • 1Department of Otolaryngology-Head & Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7070, USA. austin_rose@med.unc.edu

Pediatric Clinics of North America
|August 3, 2013
PubMed

Insights

Chronic rhinosinusitis (CRS) impacts millions annually, costing billions. Ongoing research into innate and environmental factors offers hope for better understanding and treatment of this complex condition, especially in children.

Area of Science:

  • Otolaryngology
  • Immunology
  • Environmental Health

Background:

  • Chronic rhinosinusitis (CRS) is a prevalent condition affecting millions in the US.
  • CRS incurs substantial direct and indirect healthcare costs.
  • Current understanding of CRS pathophysiology and optimal treatments remains limited and controversial.

Purpose of the Study:

  • To explore recent advances in basic science research for CRS.
  • To improve understanding of the innate and environmental factors contributing to CRS pathophysiology.
  • To identify potential pathways for improved treatment strategies for CRS.

Main Methods:

  • Review of current basic science research on CRS.
  • Analysis of innate immune system factors in CRS.
  • Investigation of environmental influences on CRS development and progression.

Main Results:

  • Recent basic science research shows promise in elucidating CRS pathophysiology.
  • Emerging data highlights the role of innate and environmental factors.
  • Understanding these factors may lead to novel therapeutic approaches.

Conclusions:

  • Further research into the fundamental mechanisms of CRS is crucial.
  • Advances in understanding innate and environmental factors are key to improving patient outcomes.
  • This knowledge holds promise for developing more effective treatments for CRS, including in pediatric populations.

Keywords:
Chronic rhinosinusitisManagementPediatric sinusitisSurgeryTreatment

More Related Videos

Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation06:13

Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation

Published on: June 20, 2018

Related Concept Videos

Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Common Respiratory Disorders01:31

Common Respiratory Disorders

Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...