Association between MTR A2756G polymorphism and childhood acute lymphoblastic leukemia: a meta-analysis
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Published on: October 11, 2018
Jia Xia1, Yadan Wang, Hang Zhang
1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei , China.
Abstract:
Abstract To date, many studies on the association between methionine synthase (MTR) A2756G and childhood acute lymphoblastic leukemia (ALL) have provided either controversial or inconclusive results. To clarify the effect of MTR A2756G on the risk of childhood acute lymphoblastic leukemia, a meta-analysis of all relevant studies was performed. The fixed effects model showed that the 2756A allele was associated with a decreased risk of childhood ALL compared with the G allele (ORA vs. G = 0.872; 95% CI 0.782-0.974; p = 0.015, I(2) = 46.9%). Additionally, when comparing subjects with ALL and controls with AA vs. AG or AA vs. AG + GG (dominant model), significant differences were found in the fixed effects model (ORAA vs. AG = 0.869; 95% CI 0.760-0.994; p = 0.040, I(2) = 26.4%; ORAA vs. AG+ GG = 0.858; 95% CI 0.754-0.976; p = 0.020, I(2) = 39.6%). In a subgroup analysis in a population with the same background, individuals with the AA genotype had a reduced risk of developing ALL compared to individuals with the AG genotype. In conclusion, our study provides evidence suggesting that MTR A2756G is associated with a reduced risk of developing childhood ALL.
Insights
The methionine synthase (MTR) A2756G gene variant is associated with a reduced risk of childhood acute lymphoblastic leukemia (ALL). This finding suggests a protective effect of the MTR A2756G polymorphism against ALL development in children.
Area of Science:
- Genetics
- Pediatric Oncology
- Molecular Biology
Background:
- The association between methionine synthase (MTR) A2756G polymorphism and childhood acute lymphoblastic leukemia (ALL) has yielded inconsistent results.
- Clarifying this genetic link is crucial for understanding ALL risk factors.
Purpose of the Study:
- To conduct a comprehensive meta-analysis to determine the effect of the MTR A2756G polymorphism on the risk of childhood ALL.
Main Methods:
- A meta-analysis was performed on relevant published studies.
- Fixed effects models were used to analyze the association between MTR A2756G genotypes and childhood ALL risk.
- Subgroup analyses were conducted on populations with similar genetic backgrounds.
Main Results:
- The 2756A allele showed a decreased risk of childhood ALL compared to the G allele (OR = 0.872, P = 0.015).
- Dominant models (AA vs. AG and AA vs. AG + GG) also indicated a significant reduction in ALL risk (OR = 0.869, P = 0.040 and OR = 0.858, P = 0.020, respectively).
- Subgroup analysis confirmed a reduced risk in individuals with the AA genotype compared to the AG genotype.
Conclusions:
- The MTR A2756G polymorphism is associated with a reduced risk of developing childhood ALL.
- This genetic variant may play a protective role in the etiology of childhood ALL.
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